2024年08月
- Concise Total Syntheses of (−)-Crinipellins A and B Enabled by a Controlled Cargill Rearrangement
- Total Synthesis of (-)-Rauvomine B via a Strain-promoted Intramolecular Cyclopropanation
- Total Synthesis of (+)-Kalmanol
- Total Synthesis of Ganoapplanin Enabled by a Radical Addition-Aldol Reaction Cascade
- Mechanism-exercises-August-1
- Mechanism-exercises-August-2
- Mechanism-exercises-August-3
- Mechanism-exercises-August-4
2024年06月
- A Unified Synthetic Approach to the Pleurotin Natural Products
- Concise Total Synthesis of (-)-BipolaroliD
- Divergent and gram-scale syntheses of (–)-veratramine and (–)-cyclopamine
- Divergent Synthesis of Scabrolide A and Havellockite via an exo-exo-endo Radical Cascade
- Mechanism-exercises-June-1
- Mechanism-exercises-June-2
- Mechanism-exercises-June-3
- Mechanism-exercises-June-4
2024年04月
- Navigating Excess ComplexityTotal Synthesis of Daphenylline
- Total syntheses of Tetrodotoxin and 9-epi Tetrodotoxin
- Total Synthesis of (±)-Rubriflordilactone A
- Total Synthesis of Keramaphidin B and Ingenamine by Base-Catalyzed Diels-Alder Reaction Using Dynamic RegioselectiveCrystallization
- Mechanism-exercises-April-1
- Mechanism-exercises-April-2
- Mechanism-exercises-April-3
- Mechanism-exercises-April-4
2024年03月
- Asymmetric Total Synthesis of Pedrolide
- Aza-Achmatowicz rearrangement coupled withintermolecular aza-Friedel-Crafts enables totalsyntheses of uleine and aspidosperma alkaloidst
- Enantioselective Total Synthesis of (-)-Daphenylline
- Enantioselective Total Synthesis of (-)-Hunterine A Enabled by aDesymmetrizationRearrangement Strategy
- Mechanism-exercises-March-1
- Mechanism-exercises-March-2
- Mechanism-exercises-March-3
- Mechanism-exercises-March-4
2023年12月
- Total Synthesis of (-)-Batrachotoxin Enabled by a PdAg-PromotedSuzuki-Miyaura Coupling Reaction
- Total Synthesis of (+)-Euphorikanin A via an Atropospecific Cascade
- Total Synthesis of Taxol Enabled by Intermolecular Radical Coupling and Pd-Catalyzed Cyclization
- Mechanism-exercises-December-1
- Mechanism-exercises-December-2
- Mechanism-exercises-December-3
2023年11月
- Catalytic Asymmetric Total Synthesis of (−)-Garryine via an Enantioselective Heck Reaction
- Enantioselective Total Syntheses of (−)-Caulamidine D and (−)-Isocaulamidine D and Their Absolute Configuration Reassignment
- Total Syntheses of Polycyclic Diterpenes Phomopsene, Methyl Phomopsenonate, and iso-Phomopsene via Reorganization of C–C Single Bonds
- Mechanism-exercises-November-1
- Mechanism-exercises-November-2
- Mechanism-exercises-November-3
- Mechanism-exercises-November-4
2023年9月
- A Homo-Mannich Reaction Strategy Enables Collective Access toIbophyllidine,Aspidosperma,Kopsia,and Melodinus Alkaloids
- Convergent Total Synthesis of (−)-Cyclopamine
- Divergent Total Syntheses of Illicium Sesquiterpenes through Late-Stage Skeletal Reorganization
- Streamlined Strategy for Scalable and Enantioselective Total Syntheses of the Eburnane Alkaloids.
- Mechanism-exercises-September-1
- Mechanism-exercises-September-2
- Mechanism-exercises-September-3
- Mechanism-exercises-September-4
2023年5月
- Oxidative Coupling Approachto Sarpagine Alkaloids Total Synthesisof (-)-Trinervine,Vellosimine,(+)-NormacusineB, and (-)-AlstomutinineC
- Total Synthesis of (−)-Retigeranic Acid A A Reductive Skeletal Rearrangement Strategy
- Total Synthesis of (+)-Aberrarone
- Mechanism-exercises-May-1
- Mechanism-exercises-May-2
- Mechanism-exercises-May-3
2023年3月
- Asymmetric Total Synthesis of Twin Bufogargarizins A and B
- Enantioselective Total Synthesis of (−)-Himalensine A via a Palladium and 4-Hydroxyproline Co-catalyzed Desymmetrization of Vinyl-bromide-tethered Cyclohexanones
- Enantioselective Total Synthesis of (+)-Alterbrassicicene C
- Enantioselective Total Synthesis of (+)-Stephadiamine
- Mechanism-exercises-March-1
- Mechanism-exercises-March-2
- Mechanism-exercises-March-3
- Mechanism-exercises-March-4
2023年2月
- A 15-step synthesis of (+)-Ryanodol
- A Convergent Total Synthesis of (+)-Ineleganolide
- Asymmetric Total Synthesis of Illisimonin A
- Asymmetric Total Synthesis of Naphthospironone A
- Mechanism-exercises-February-1
- Mechanism-exercises-February-2
- Mechanism-exercises-February-3
- Mechanism-exercises-February-4
2022年11月
- Asymmetric Total Synthesis of Havellockate
- Total Synthesis of (-)-Principinol C
- Total Synthesis of (+)-Cochlearol Approach Based on a Catellani Reaction andB by an Visible-Light-Enabled [2＋2] Cycloaddition
- Total Synthesis of Yuzurine-type Alkaloid Daphgraciline
- Mechanism-exercises-November-1
- Mechanism-exercises-November-2
- Mechanism-exercises-November-3
- Mechanism-exercises-November-4
2022年09月
- Enantioselective Total Synthesis of (-)-Limaspermidine and (-)-Kopsinine by a Nitroaryl Transfer Cascade Strategy
- Stereoselective Total Synthesis of (-)-Thallusin for Bioactivity Profiling
- Total Syntheses of Calyciphylline A-Type Alkaloids (-)-Deoxydaphnipaxianine A,(+)-Daphlongamine E and (+)-Calyciphylline R via Late-Stage Divinyl Carbinol Rearrangements
- Mechanism-exercises-September-1
- Mechanism-exercises-September-2
- Mechanism-exercises-September-3
2022年08月
- Asymmetric Total Synthesis of (+)-Alstonlarsine A
- Biomimetic Total Synthesis of the Spiroindimicin Family of Natural Products
- Divergent Total Syntheses of Napelline-Type C20-Diterpenoid Alkaloids，(-)-Napelline,(+)-Dehydronapelline,(-)-Songorine,(-)-Songoramine,(-)-Acoapetaldine D, and (-)-Liangshanone
- Mechanism-exercises-August-1
- Mechanism-exercises-August-2
- Mechanism-exercises-August-3
2022年05月
- Concise Enantioselective Total Synthesis of Daphenylline Enabled by an Intramolecular Oxidative Dearomatization
- Total Synthesis of (+)-Cochlearol B by an Approach Based on a Catellani Reaction and Visible-Light-Enabled [2+2] Cycloaddition
- Two-Stage Syntheses of Clionastatins A and B
- Mechanism-exercises-May-1
- Mechanism-exercises-May-2
- Mechanism-exercises-May-3
2022年04月
- Asymmetric Total Syntheses of Schizozygane Alkaloids
- Bidirectional Total Synthesis of PhainanoidA via Stratedgic Use of Ketones
- Catalytic, Asymmetric Total Synthesis of (+)-α-,(+)-β-,(+)-y-,and (-)-6-Lycorane
- Divergent Total Synthesis of Four Kopsane Alkaloid N-Carbomethoxy-10,22-dioxokopsane,Epikopsanol-10-lactam,10,2-Dioxokopsane, and N-Methylkopsanone
- Mechanism-exercises-April-1
- Mechanism-exercises-April-2
- Mechanism-exercises-April-3
- Mechanism-exercises-April-4
2021年12月
- Asymmetric Total Synthesis of Indole Diterpenes Paspalicine, Paspalinine, and Paspalinine-13-ene
- Catalysis-Enabled Concise and Stereoselective Total Synthesis of the Tricyclic Prostaglandin D2 Metabolite Methyl Ester
- Total Synthesis of the Potent and Broad-Spectrum Antibiotics Amycolamicin and Kibdelomycin
- Mechanism-exercises-December-1
- Mechanism-exercises-December-2
- Mechanism-exercises-December-3
2021年09月
- A Concise Enantioselective Total Synthesis of (−)-Virosaine A
- A Unified Approach to Polycyclic Alkaloids of the Ingenamine Estate Total Synthesis of Keramaph B, Ingenamine, and Nominal Njaoamine I
- Flow Chemistry-Enabled Divergent and Enantioselective Total Syntheses of Massarinolin A, Purpurolides B, D, E, 2,3-Deoxypurpurolide C, and Structural Revision of Massarinolin A
- Mechanism-exercises-September-1
- Mechanism-exercises-September-2
- Mechanism-exercises-September-3
2021年07月
- Asymmetic Total Synthesis of Hetidine-Type C20-Diterpenoid Alkaloids (+)-Talassimidine and (+)-Talassamine
- Asymmetric Total Syntheses of (+)-Davisinol and (+)-18-Benzoyldavisiol A HAT-Initiated Transannulal Redox Radical Approach
- Total Synthesis of (+)-3-Deoxyfortalpinoid F, (+)-Fortalpinoid A, and (+)-Cephinoid H
- Mechanism-exercises-July-1
- Mechanism-exercises-July-2
- Mechanism-exercises-July-3
2021年03月
- Collective Asymmetric Total Synthesis of C-11 Oxygenated Cephalotaxus Alkaloids
- Enantioselective Total Synthesis of (+)-Stephadiamine through Bioinspired Aza-Benzilic Acid Type Rearrangement
- Total Synthesis of (+)-Alsmaphorazine C and Formal Synthesis of (+)-Strictamine A Photo-Fries Approach
- Total Synthesis of the Cephalotaxus Norditerpenoids Cephanolides A-D
- Mechanism-exercises-March-1
- Mechanism-exercises-March-2
- Mechanism-exercises-March-3
- Mechanism-exercises-March-4
2021年01月
- Enantioselective Synthesis of Euonyminol
- Divergent Total Synthesis of Euphoranginol C, Euphoranginone D, ent‐Trachyloban‐3β‐ol, ent‐Trachyloban‐3‐one, Excoecarin E, and ent‐16α‐Hydroxy‐atisane‐3‐one
- Mechanism-exercises-January-1
- Mechanism-exercises-January-2
- Mechanism-exercises-January-3
- Mechanism-exercises-January-4
2020年12月
- Stereocontrolled Total Synthesis of (−)-Isocelorbicol and Its Elaboration to Natural Dihydro-β-agarofuran Esters
- Collective Total Synthesis of Casbane Diterpenes One Strategy, Multiple Targets
- Asymmetric Total Synthesis of Dankasterones A and B and Periconiastone A Through Radical Cyclization
- Mechanism-exercises-December-1
- Mechanism-exercises-December-2
- Mechanism-exercises-December-3
- Mechanism-exercises-December-4
2020年11月
- Total Synthesis of (+)-Haperforin G
- Enantioselective total syntheses of (+)-Stemofoline and three Congeners based on a biogenetic hypothesis
- Asymmetric Total Synthesis of the Highly Strained 4β-Acetoxyprobotryane-9β,15α-diol
- Mechanism-exercises-November-1
- Mechanism-exercises-November-2
- Mechanism-exercises-November-3
- Mechanism-exercises-November-4
2020年05月
- Asymmetric Total Synthesis of (−)-Spirochensilide A
- Enantioselective Total Synthesis of Cotylenin A
- The Total Synthesis of (−)-Scabrolide A
- Total Synthesis of (-)-Pepluanol B Conformational Control of the Eight-Membered-Ring System
- Total Synthesis of (-)-Rhodomollanol A
- Mechanism-exercises-May-1
- Mechanism-exercises-May-2
- Mechanism-exercises-May-3
- Mechanism-exercises-May-4
- Mechanism-exercises-May-5
2019年12月
- Enantioselective Total synthesis of Lyconadins A-E through A palladium-catalyzed Heck-type reaction
- Total synthesis of (+)-6-epi-Ophiobolin A
- Total Synthesis and Structural Revision of a Harziane Diterpenoid
- Synthesis of (−)-Mitrephorone A via a Bioinspired Late Stage C−H
- Mechanism-exercises-December-1
- Mechanism-exercises-December-2
- Mechanism-exercises-December-3
- Mechanism-exercises-December-4
2019年6月
- Mechanism exercises-June-3
- Mechanism exercises-June-1
- Mechanism exercises-June-2
- Convergent Total Synthesis of Pricipinol D a Rearranged Kaurane Diterpenoid
- Enantioselective Total Synthesis of Pseudopteroxazole and
- Synthesis of (+)-Darwinolide, a Biofilm-Penetrating Anti-MRSA Agent
- Total Synthesis of (-)-Ambigunine P